The following is a list of Sites of Special Scientific Interest in the Mid and East Lothian Area of Search, in Scotland. For other areas, see the list of SSSIs by Area of Search.
- Aberlady Bay LNR
Auchencorth Moss
- Bangley Quarry
- Barns Ness Coast
- Bass Rock
- Bilston Burn
- Black Burn
- Crichton Glen
- Dalkeith Oakwood
- Danskine Loch
- Dundreich Plateau
- Fala Flow
- Firth of Forth
- Forth Islands
- Garleton hills
- Gladhouse Reservoir
- Habbies Howe - Logan Burn
- Hadfast Valley
- Hewan Bank
- Keith Water
- Lammer Law
- Lammermuir Deans
- Levenhall Links
- Moorfoot Hills
- Newhall Glen
- North Berwick Law
- North Esk Valley
- Papana Water
- Peeswit Moss
- Rammer Cleugh
- Roslin Glen
- Traprain Law
- Woodhall Dean